Rising and falling on the social ladder: The bidimensional social mobility beliefs scale.

Recent works in the field of Social Psychology have shown the importance of studying subjective social mobility from different perspectives. In the literature about subjective societal mobility, most of the research is focused on the mobility-immobility framing. However, several authors suggested studying social mobility beliefs effects differentiating according to mobility's trajectory, that is, upward (i.e., improving status over time) and downward (i.e., getting worse in status over time). The present research was motivated by the lack of measures that discriminate between beliefs in upward and downward societal mobility. Across two studies using different samples of the Spanish adult population, we examined both dimensions of social mobility beliefs and tested their predictive validity on other related constructs. In Study 1 (N = 164), with an EFA, we corroborated the independence between the two types of mobility. The internal structure was confirmed by a CFA in Study 2 (N = 400). Furthermore, it was shown that upward and downward mobility beliefs are differently related to other related constructs. The results from Studies 1-2 showed good convergent validity. In all correlations with the different constructs (attitudes towards inequality, meritocratic beliefs, justification of the economic system, and status anxiety) we found opposite direction effects for both types of societal mobility (upward and downward). The development of this new instrument can help to deepen our understanding of the psychosocial consequences of subjective social mobility, as well as to differentiate two processes that may have different consequences.

How Much Dialogic Coordination Practices Matter to Healthcare Professionals-A Delphi Approach towards a Tool for Identification and Measurement.

The study of coordination practices in health policy is a central aspect. The need for further research has been recently highlighted because of COVID-19. In this sense, dialogic practices (DP) have been identified but not validated yet. The purpose of this study is to develop and validate a DP questionnaire for healthcare teams. Items were identified based on a literature review, and the content validation was carried out by means of a Delphi study. A total of 10 experts assessed the clarity and appropriateness of the items and their corresponding measurement scales. After two rounds, a high level of consensus was reached, with agreement of 90% or higher on all items, and a high degree of stability and concordance in the results. This study resulted in a questionnaire consisting of four items, one for each identified DP initially proposed to the experts, as no other practices were revealed. From a practical perspective, the validation of these items constitutes a methodological innovation that responds to the call in the literature to open new avenues for comparative studies, and the possibility of generalising the findings and bringing together different approaches to the problem of coordination, which is key in health policy where unforeseen situations emerge.

Experimental Analysis and Application of a Multivariable Regression Technique to Define the Optimal Drilling Conditions for Carbon Fiber Reinforced Polymer (CFRP) Composites.

Carbon fiber reinforced polymers (CFRPs) are interesting materials due to their excellent properties, such as their high strength-to-weight ratio, low thermal expansion, and high fatigue resistance. However, to meet the requirements for their assembly, the drilling processes involved should be optimized. Defects such as delamination, dimensional errors and poor internal surface finish can lead to the premature failure of parts when bolt-joined or rivet-connected. In addition, the characteristic anisotropy and heterogeneity of these materials, and the issues related to the temperature reached during drilling, make it difficult to obtain optimal cutting parameters or to achieve high material removal rates. This research focuses on the optimization of the CFRPs drilling process by means of experimental analysis-varying the feed and spindle speed-for two different types of commercial drills-a twist tool and a dagger tool. An automatic image processing methodology was developed for the evaluation of the dimensional accuracy and delamination of the holes. The optimization was carried out using a multi-objective regression technique based on the dimensional deviations, delamination and surface finish. The areas with favorable machining conditions have been delimited for both tools and the results indicate that the twist tool allows one to achieve more productive cutting conditions than the dagger tool, when the combination of low feeds and high spindle speeds are the conditions to be avoided.

Gendered Social Perceptions of "The Poor": Differences in Individualistic Attributions, Stereotypes, and Attitudes Toward Social Protection Policies.

Poverty is a phenomenon that affects men and women differently. In the current research, we examined social perceptions of poor men and women across three experiments focusing on attributions for poverty, classist attitudes, and stereotypes about poor people. In Study 1, participants from the general population (N = 484) made more individualistic (dispositional) attributions for men's poverty compared to women's poverty, blaming men more for their poverty. Participants also believed that men would manage the assistance they received from the state more poorly than women. These patterns were observed across all three studies. In Study 2 (N = 256), we also found that more individualistic attributions for why men were in poverty predicted more negative attitudes toward social protection policies concerning men. In Study 3 (N = 358), we replicated the results observed in Study 2, and found that women in poverty were described as mor communal and competent than men in poverty. We interpret these results considering the operation of traditional gender roles as well as the parallelism between stereotypes of women and poor people. Our results are relevant to the framing of the proposals by social organizations, political parties, and emancipation movements that advocate for policies and programs to address poverty. Supplementary Information: The online version contains supplementary material available at 10.1007/s11199-023-01375-9.

Wage (in)equality matters: the effect of organizational economic inequality on others' and self-ascriptions.

Economic inequality has consequences at the social-psychological level, such as in the way people make inferences about their environment and other people. In the present two preregistered studies, we used a paradigm of an organizational setting to manipulate economic inequality and measured ascriptions of agentic versus communal traits to employees and the self. In Study 1 (N = 187), participants attributed more agency than communion to a middle-status employee, and more communion than agency when economic equality was salient. In Study 2 (N = 198) this finding was replicated. Further, this inequality-agency association was explained by perceptions of competitive employee relationships. Results, moreover, suggested that participants mainly attributed more communion than agency to themselves in the equality condition. We conclude that agency and communion ascriptions may be functional and thus inform about the expectations people have on the nature of social relationships in the face of economic inequality.

Safety and efficacy of intra-arterial bone marrow mononuclear cell transplantation in patients with acute ischaemic stroke in Spain (IBIS trial): a phase 2, randomised, open-label, standard-of-care controlled, multicentre trial.

BACKGROUND: Pilot clinical trials have shown the safety of intra-arterial bone marrow mononuclear cells (BMMNCs) in stroke. However, the efficacy of different doses of intra-arterial BMMNCs in patients with acute stroke has not been tested in a randomised clinical trial. We aimed to show safety and efficacy of two different doses of autologous intra-arterial BMMNC transplantation in patients with acute stroke. METHODS: The IBIS trial was a multicentre phase 2, randomised, controlled, investigator-initiated, assessor-blinded, clinical trial, in four stroke centres in Spain. We included patients (aged 18-80 years) with a non-lacunar, middle cerebral artery ischaemic stroke within 1-7 days from stroke onset and with a National Institutes of Health Stroke Scale score of 6-20. We randomly assigned patients (2:1:1) with a computer-generated randomisation sequence to standard of care (control group) or intra-arterial injection of autologous BMMNCs at one of two different doses (2 × 106 BMMNCs/kg or 5 × 106 BMMNCs/kg). The primary efficacy outcome was the proportion of patients with modified Rankin Scale scores of 0-2 at 180 days in the intention-to-treat population, comparing each BMMNC dose group and the pooled BMMNC group versus the control group. The primary safety endpoint was the proportion of serious adverse events. This trial was registered at ClinicalTrials.gov, NCT02178657 and is completed. FINDINGS: Between April 1, 2015, and May 20, 2021, we assessed 114 patients for eligibility. We randomly assigned 77 (68%) patients: 38 (49%) to the control group, 20 (26%) to the low-dose BMMNC group, and 19 (25%) the high-dose BMMNC group. The mean age of participants was 62·4 years (SD 12·7), 46 (60%) were men, 31 (40%) were women, all were White, and 63 (82%) received thrombectomy. The median NIHSS score before randomisation was 12 (IQR 9-15), with intra-arterial BMMNC injection done a median of 6 days (4-7) after stroke onset. The primary efficacy outcome occurred in 14 (39%) patients in the control group versus ten (50%) in the low-dose group (adjusted odds ratio 2·08 [95% CI 0·55-7·85]; p=0·28), eight (44%) in the high-dose group (1·89 [0·52-6·96]; p=0·33), and 18 (47%) in the pooled BMMNC group (2·22 [0·72-6·85]; p=0·16). We found no differences in the proportion of patients who had adverse events or dose-related events, but two patients had a groin haematoma after cell injection in the low-dose BMMNC group. INTERPRETATION: Intra-arterial BMMNCs were safe in patients with acute ischaemic stroke, but we found no significant improvement at 180 days on the mRS. Further clinical trials are warranted to investigate whether improvements might be possible at different timepoints. FUNDING: Instituto de Salud Carlos III co-funded by the European Regional Development Fund/European Social Fund, Mutua Madrileña, and the Regional Ministry of Health of Andalusia.

Perceived economic inequality enlarges the perceived humanity gap between low- and high-socioeconomic status groups.

In this paper, we analyze the influence of the perceived level of economic inequality in daily life on people's recognition of the perceived humanity gap between low- and high-socioeconomic groups within society. To achieve this purpose, in Studies 1A-B, we analyzed the relationship between economic inequality and the humanity gap. In Studies 2A-B, we manipulated the level of inequality (low vs. high) to identify differences in the humanity gap. Results indicated that higher perceptions of economic inequality lead individuals to recognize a wider humanity gap between low- and high-socioeconomic groups in society. Implications are discussed.

Not all poor are equal: the perpetuation of poverty through blaming those who have been poor all their lives.

The economic crisis of 2008 severely affected the welfare states. As the economic situation of a country worsens, the resources that the public administration can devote to improve the situation of the people also decrease, endangering the advancement of those in a disadvantaged situation. People who have always lived in poverty, besides having their opportunities reduced, also face negative public views that affect the perceived legitimacy of such public aid, which can in turn be a mechanism for perpetuating their situation. Two studies (N = 252 and N = 266) analyse how a person in persistent poverty is perceived compared to a person in poverty due to the crisis-a circumstantial poverty. We also study some feasible mechanisms underlying this different perception, as well as their effects on attitudes toward social protection policies. In Study 1, results indicated that people showed more favourable attitudes toward social protection policies when they perceived someone in poverty due to the crisis, compared to the target who had been in poverty all his/her life. Individualistic attributions for poverty mediated this effect: when people think of someone in persistent poverty, they make more individualistic attributions concerning their situation, which leads to worse attitudes toward social protection policies. Identification with the group moderates this relation. Furthermore, Study 2 showed that participants perceive people who are in poverty because of economic crisis as more deserving of help than people who have always been poor. Some theoretical and practical implications for intergroup relations and public policy are discussed. Supplementary Information: The online version contains supplementary material available at 10.1007/s12144-022-03804-6.

Express improvement of acute stroke care accessibility in large regions using a centralized telestroke network.

Introduction: Acute ischemic stroke therapy has improved in recent decades, decreasing the rates of disability and death among stroke patients. Unfortunately, all health care systems have geographical disparities in infrastructure for stroke patients. A centralized telestroke network might be a low-cost strategy to reduce differences in terms of geographical barriers, equitable access, and quality monitoring across different hospitals. Aims: We aimed to quantify changes in stroke patients' geographic access to specialized evaluation by neurologists and to intravenous acute stroke reperfusion treatments following the rapid implementation of a centralized telestroke network in the large region of Andalusia (8.5 million inhabitants). Methods: We conducted an observational study using spatial and analytical methods to examine how a centralized telestroke network influences the quality and accessibility of stroke care for a large region. Results: In the pre-implementation period, 5,005,477 (59.72% of the Andalusian population) had access to specialized stroke care in less than 30 min. After the 5-month process of implementing the telestroke network, 7,832,988 (93.5%) inhabitants had an access time of less than 30 min, bridging the gap in acute stroke care in rural hospitals. Conclusions: A centralized telestroke network may be an efficient tool to reduce the differences in stroke care access and quality monitoring across different hospitals, especially in large regions with low population density.

Are you ready for retirement? The influence of values on membership in voluntary organizations in midlife and old age.

Membership in voluntary organizations is associated with individual and social benefits. Due to the negative consequences of the global pandemic on older people, and the governmental challenges posed by population aging, voluntary membership is of great importance to society. To effectively promote volunteering among older people, it is necessary to understand the determinants of voluntary membership. This study analyses the influence of individual values-secular/traditional and survival/self-expression-on voluntary membership among European adults (N = 31,985). Specifically, it examines which values orient two age groups (middle age: 50-64 and old age: 65-79), as well as men and women toward a certain type of association (Social Awareness; Professional and Political; Education and Leisure; Religion). The sample of 31,985 comprises 60% of adults aged 50-64 and 40% aged 65-79; of which 56% are women and 44% men. The empirical estimation considers different levels of data aggregation: individual, national and welfare system, therefore multilevel analysis is used as an analytical strategy. Individual-level variables from the Integrated Values Survey (2005/09, 2010/14, and 2017/20) and national-level variables (Gini Index and Gross Domestic Product Per Capita) from the World Bank and Eurostat are used. The results indicate that traditional and self-expression values promote membership in voluntary organizations in general more than secular and survival values. However, there are differences according to the type of organization. Furthermore, values are found to moderate the effect of age and gender on voluntary membership.

What about diversity? The effect of organizational economic inequality on the perceived presence of women and ethnic minority groups.

Economic inequality shapes the degree to which people and different social groups are perceived in stereotypical ways. Our research sought to investigate the impact of the perception of economic inequality in an organizational setting on expectations of social diversity in the organization's workforce, across the dimensions of gender and ethnicity. Combining data from previous experiments, we first explored in one set of studies (Studies 1a and 1b; N = 378) whether the degree of economic inequality in a fictitious organization affected participants' expectations of the representation of minority vs. majority group employees. We found that when we presented an organization with unequal (vs. equal) distribution of economic wealth amongst its employees to study participants, they expected the presence of men and White majority individuals to be larger than the presence of women and ethnic minorities. Second, we tested our hypotheses and replicated these initial effects in a pre-registered study (Study 2: N = 449). Moreover, we explored the potential mediating role of perceived diversity climate, that is, the perception that the organization promotes and deals well with demographic diversity. Findings revealed that an organizational setting that distributed resources unequally (vs. equally) was associated with a more adverse diversity climate, which, in turn, correlated with expectations of a lower presence of minority group employees in the organization. We concluded that economic inequality creates a context that modulates perceptions of a climate of social exclusion which likely affects the possibilities for members of disadvantaged groups to participate and develop in organizations.

Differential Outcomes Following 4 Weeks of Aclidinium/Formoterol in Patients with COPD: A Reanalysis of the ACTIVATE Study.

Rationale: It is difficult to predict the effects of long-acting bronchodilators (LABD) on lung function, exercise capacity and physical activity in patients with chronic obstructive pulmonary disease (COPD). Therefore, the multidimensional response to LABD was profiled in COPD patients participating in the ACTIVATE study and randomized to LABD. Methods: In the ACTIVATE study, patients were randomized to aclidinium bromide/formoterol fumarate (AB/FF) or placebo for four weeks. The primary outcomes included (1) lung function as measured by functional residual capacity (FRC), residual volume (RV), and spirometric outcomes; (2) exercise performance as measured by a constant work rate cycle ergometry test (CWRT); and (3) physical activity (PA) using an activity monitor. Self-organizing maps (SOMs) were used to create an ordered representation of the patients who were randomly assigned to four weeks of AB/FF and cluster them into different outcome groups. Results: A total of 250 patients were randomized to AB/FF (n = 126) or placebo (n = 124). Patients in the AB/FF group (39.6% women) had moderate-to-severe COPD, static hyperinflation (FRC: 151.4 (27.7)% predicted) and preserved exercise capacity. Six clusters with differential outcomes were identified. Patients in clusters 1 and 2 had significant improvements in lung function compared to the remaining AB/FF-treated patients. Patients in clusters 1 and 3 had significant improvements in CWRT time, and patients in clusters 2, 3 and 6 had significant improvements in PA compared to the remaining AB/FF-treated patients. Conclusion: Individual responses to 4 weeks of AB/FF-treatment in COPD are differential and the degree of change differs across domains of lung function, exercise capacity and PA. These results indicate that clinical response to LABD therapy is difficult to predict and is non-linear, and show doctors that it is important to look at multiple outcomes simultaneously when evaluating the clinical response to LABD therapy. Clinical Trial Registration: The original ACTIVATE study was registered on ClinicalTrials.gov, registration number NCT02424344.

Neurocognitive and emotional status after one-year of mindfulness-based intervention in patients with relapsing-remitting multiple sclerosis.

Multiple sclerosis (MS) is the most common disabling neurological disease among young adults. The diagnosis of this disease usually leads to uncertainty, stress, and anxiety, which in turn can lead to negative outcomes. Consequently, the development of healthy lifestyle strategies can lead to better emotional management of perceived stress. Due to the importance of the patient's emotional response during the development and management of the disease and the repercussions of the cognitive deficits, the objective of this study is to develop a mindfulness-based intervention to provide to patients a tool for stress management. This study offers data on neuropsychological, functional and emotional outcomes in a sample of 30 patients with remitting relapsing form of MS after one year of intervention compared to 30 controls. We tested a model of intervention with a program of Mindfulness-Based Cognitive Therapy, based on an adapted Jon Kabat-Zinn's MBSR program. Results showed cognitive and emotional benefits after one year following this program. Discussion about the opportunities of these types of intervention in neurological diseases is provided in light of results obtained. This study represents pioneering research in MS and psychological treatment of this neurological autoimmune disease and it offers positive results of applying mindfulness-based intervention in this population.

Dangerous Worldview and Perceived Sociopolitical Control: Two Mechanisms to Understand Trust in Authoritarian Political Leaders in Economically Threatening Contexts.

In this research we analyzed the relationship between threatening economic contexts (i.e., undergoing the economic crisis and having low socioeconomic status) and trust in authoritarian ideologies and leaders, regardless of the left-right political axis. Based on two theoretical approaches (i.e., the dual-process model and the compensatory control model), we argue that this relationship is mediated by dangerous worldview and low perceived sociopolitical control. We conducted two correlational studies with samples of the general population. In Study 1 (N = 185), we found that perceived threat from the economic crisis and low socioeconomic status were correlated with a higher dangerous worldview, which resulted in a more authoritarian ideology (i.e., authoritarianism) and finally in greater trust in an authoritarian political leader. In Study 2 (N = 413), we replicated the findings of Study 1 and demonstrated that low perceived sociopolitical control was associated with higher authoritarianism. Moreover, low perceived sociopolitical control partially mediated the relationship between dangerous worldview and authoritarianism. Overall, our results show that two economically threatening contexts (i.e., the economic crisis and low socioeconomic status) promote authoritarianism and trust in authoritarian leaders (with unspecified political orientation) through psychological processes (i.e., perception of the social world and perceived control). These results are useful to understand and combat the rise of authoritarianism in our societies during financially difficult times such as economic crises.

Evolution of gender stereotypes in Spain: from 1985 to 2018 / Evolución de los Estereotipos de Género en España: de 1985 a 2018

BACKGROUND: Gender stereotypes are the images, beliefs, or expectations that people have about men and women. Have these stereotypes changed in Spain in recent decades? METHOD: In this study we present data on gender stereotypes in Spain in two different time periods (1985, N = 1060; and 2018, N = 802). RESULTS: Results indicate that of the four components of the stereotypes analyzed (traits, role behaviors, occupations, and physical characteristics), the stereotypes in three of them have changed. In role behaviors and occupations, people perceive that men have increased their presence in female-linked gender roles and occupations, and that women have increased their presence in roles and occupations that are traditionally male-linked. Women in 2018 are more associated with physical characteristics traditionally associated with men, but men are not perceived as more associated with physical characteristics traditionally linked to women. In personality traits the stereotype has not changed: In agentic traits there were no differences between men and women in 1985 and in 2018; and communal traits were more attributed to women than men in 1985 and in 2018. CONCLUSIONS: These results show that although gender stereotypes still exist in Spain, they have changed considerably, at least in several dimensions

ANTECEDENTES: los estereotipos de género son las imágenes, creencias o expectativas que las personas tienen sobre hombres y mujeres. ¿Han cambiado estos estereotipos en España en las últimas décadas? MÉTODO: presentamos datos sobre los estereotipos de género en España en dos periodos (1985, N =1060; y 2018, N = 802). RESULTADOS: los resultados indican que de los cuatro componentes de los estereotipos analizados (rasgos, conductas de rol, ocupaciones y características físicas), en tres de ellos los estereotipos han cambiado. Se percibe que los hombres han aumentado su presencia en los roles y ocupaciones de género vinculados a las mujeres, y que las mujeres han aumentado su presencia en los tradicionalmente vinculados a los hombres. Las mujeres en 2018 aparecen más asociadas con características físicas tradicionalmente masculinas, pero los hombres no se perciben más asociados a las características físicas femeninas. En los rasgos de personalidad, el estereotipo no ha cambiado: en los agénticos no hubo diferencias entre hombres y mujeres en 1985 ni en 2018; y los rasgos comunales fueron más atribuidos a las mujeres que a los hombres en 1985 y en 2018. CONCLUSIONES: estos resultados muestran que, aunque todavía existen estereotipos de género en España, han cambiado considerablemente, al menos en algunas dimensiones

Evolution of Gender Stereotypes in Spain: From 1985 to 2018.

BACKGROUND: Gender stereotypes are the images, beliefs, or expectations that people have about men and women. Have these stereotypes changed in Spain in recent decades? METHOD: In this study we present data on gender stereotypes in Spain in two different time periods (1985, N = 1060; and 2018, N = 802). RESULTS: Results indicate that of the four components of the stereotypes analyzed (traits, role behaviors, occupations, and physical characteristics), the stereotypes in three of them have changed. In role behaviors and occupations, people perceive that men have increased their presence in female-linked gender roles and occupations, and that women have increased their presence in roles and occupations that are traditionally male-linked. Women in 2018 are more associated with physical characteristics traditionally associated with men, but men are not perceived as more associated with physical characteristics traditionally linked to women. In personality traits the stereotype has not changed: In agentic traits there were no differences between men and women in 1985 and in 2018; and communal traits were more attributed to women than men in 1985 and in 2018. CONCLUSIONS: These results show that although gender stereotypes still exist in Spain, they have changed considerably, at least in several dimensions.

Ecstasy (MDMA): A rebellion coherent with the system.

Aim: This study attempts to demonstrate the relevance of the socio-cultural model of drugs in explaining the impressive development of ecstasy in the last 45 years. Method: First the study describes the use of ecstasy by groups which have left their imprint on the substance: university students, gays, yuppies and the "New Age" movement. Then the link between ecstasy and techno music led to the socially integrated "club" phenomenon, and the "rave", which began as a rupturing, nonconformist phenomenon. Findings: According to this argument, in spite of its clearly counterculture beginnings, the "rave" movement and its most characteristic drug, ecstasy, have gradually become integrated into mainstream culture, somehow reinforcing the functioning of capitalist postmodernity. Our study explains ecstasy's history in reference to the cultural contradictions of capitalism and the functions that it currently fulfils for young people. Based on this analysis, the implications of the cultural perspective are discussed as a paradigm of research in drug use, stressing notions of subculture, myths and rituals. It also proposes a harmonious articulation of academic and common knowledge as the most appropriate method for their study. Conclusion: A cultural approach to drug use could assist in unblocking a field so in need of conceptual and empirical revision.

Stranger Harassment ("Piropo") and Women's Self-Objectification: The Role of Anger, Happiness, and Empowerment.

According to objectification theory, women's habitual exposure to sexually objectifying situations can lead them to internalize a third-person perspective of themselves in physical terms, leading women to adopt an observer's viewpoint of themselves as a body or collection of body parts that is valued principally for use or consumption by others (i.e., self-objectification). The frequency and/or intensity of situations of female objectification have generally been studied as precedents of self-objectification. Our research analyzes whether direct exposure to a particular objectifying situation, as in the case of verbal stranger harassment (called piropos in Spain), could have these same effects. We tested the consequences of exposure to piropos (vs. a control situation) on body surveillance and body shame in a sample of 329 Spanish women. The impact of verbal harassment on women's anger, anxiety, happiness, and sense of empowerment was also analyzed. The results of a moderated mediation analysis showed that exposure to piropos increased body shame through body surveillance but only in women who reacted to the piropo with happiness, empowerment, or low levels of anger. The negative effects that objectifying situations (e.g., stranger harassment) may have on women, and the importance of women's reactions and perceptions of such situations are discussed.

Lacking socio-economic status reduces subjective well-being through perceptions of meta-dehumanization.

Previous research has identified that both low- and high-socio-economic groups tend to be dehumanized. However, groups that have a deprived position are more willing to interiorize the negative perceptions that others have about them compared with affluent groups. In this project, we address the role of meta-(de)humanization (the perceived humanity one thinks is ascribed or denied to one's group) based on socio-economic status differences and its influence in the perceived psychological well-being. We conducted two studies: In Study 1 (correlational, N = 990), we analysed the relationship between socio-economic status, meta-dehumanization, and well-being. Results indicated that lower socio-economic status positively predicted more meta-dehumanization and worse well-being. Moreover, meta-dehumanization mediated the relationship between socio-economic status and well-being. In Study 2 (experimental, N = 354), we manipulated socio-economic status (low-, middle-, and high-socio-economic status conditions) to evaluate its influence on meta-dehumanization and well-being. Results indicated that individuals of low (vs. higher)-socio-economic status perceived more meta-dehumanization and reported worse well-being. Finally, a multicategorical mediational analysis indicated that low (vs. middle or high)-socio-economic status led to worse well-being through higher perceived meta-dehumanization. We discuss differences in perceived meta-(de)humanization based on groups' socio-economic status and implications on the population's well-being.

Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review.

OBJECTIVE: We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. METHODS: A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls) from southern and central Spain was included. The genes TOR1A, THAP1 and GNAL were screened using a combination of high-resolution melting analysis and direct DNA resequencing. In addition, an extensive literature search to identify original articles (published before 10 August 2020) reporting mutations in TOR1A, THAP1 or GNAL associated to dystonia was performed. RESULTS: Pathogenic or likely pathogenic variants in TOR1A, THAP1 and GNAL were identified in 0.48%, 0.57% and 0.29% of our patients, respectively. Five patients carried the variation p.Glu303del in TOR1A. A very rare variant in GNAL (p.Ser238Asn) was found as a putative risk factor for dystonia. In the literature, variations in TOR1A, THAP1 and GNAL accounted for about 6%, 1.8% and 1.1% of published dystonia patients, respectively. CONCLUSIONS: There is a different genetic contribution to dystonia of these three genes in our patients (about 1.3% of patients) and in the literature (about 3.6% of patients), probably due the high proportion of adult-onset cases in our cohort. As regards age at onset, site of dystonia onset, and final distribution, in our population there is a clear differentiation between DYT-TOR1A and DYT-GNAL, with DYT-THAP1 likely to be an intermediate phenotype.